Patients should be advised to contact their health care provider immediately for any skin changes including a new wart skin sore or bump that bleeds or does not heal or a change in the size or. Fever nausea chills headache joint aches cough diarrhea rash vomiting high blood pressure hypertension and swelling of the face arms or legs. The most common side effects of tafinlar in combination with mekinist when used in patients with melanoma that has spread to other parts of the body or cannot be removed by surgery include.
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